Any theory - any theory at all - that begins with false assumptions will produce false results. Therefore, the most fundamental task of all is to examine and get right the assumptions that underlie a theory. How do science's fundamental assumptions stand up to scrutiny? Science falls apart at a particular aspect of existence that can be defined exactly - at singularities. The whole logic of science collapses when singularities are encountered. This is fantastically problematic for science given that black holes are centred on singularities, photons are singularities, and the whole of the Big Bang Universe came from a Singularity.
What, ontologically, are singularities? Descartes gave us the answer hundreds of years ago. Singularities are minds, and from that single fact, science is turned on its head. Mind does not come from matter; matter comes from mind.